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Summary of included pre-clinical and mechanistic studies regarding the effects of GLP-1-RAs on mental health outcomes)

TRP, 5-HTP, SER, 5-HIAA were detected using a fluorescence detector with an excitation wavelength of 280 nm and emission at 340 nm

Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al

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Research suggests that GLP-1 receptors are present not only in the pancreas and gastrointestinal tract but also in key brain regions involved in reward processing and food motivation, including the nucleus accumbens and ventral tegmental area, though much of this evidence comes from preclinical studies